H. Bauke Albada, et al. have just reported (ACS Med. Chem. Lett., Just Accepted Manuscript DOI: 10.1021/ml300148v) that adding lipids attached to the sidechain of a lysine residue at the N- or C-terminal of the short antimicrobial peptide (Arg-Trp)3 significantly increased its activity. The lipidized peptides are even active against pathogenic Gram-negative bacteria.
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